Oscar Piastri converted his pole position into Feature Race victory on Sunday morning.
The eventual race winner started well away in P1 and did not relinquish this lead on the first lap. Guanyu Zhou and Liam Lawson immediately overtook Jehan Daruvala to take P2 and P3.
The first Safety Car was not very long in coming. Guilherme Samaia crashed into the track barrier and was thrown back onto the track. The race was over for the Charouz Racing System driver after less than one lap.
The race was restarted on lap 5. Drugovich was considered to have profited from the restart when he passed Daruvala. The overtaking maneuver of the day also happened on lap 5 when Liam Lawson passed Zhou and temporarily took P2.
The next Safety Car also then came sooner than expected. Juri Vips apparently had a problem and had to park his car. Almost all drivers came into the pits to change tires, Ticktum stayed out and thus took the lead. Marino Sato also had a problem with the car and had to park it off the track. On lap 10, the Safety Car came in and the race went underway once again.
On lap 18, Daruvala had another mishap when he had a lock-up in turn 1, after which he had to use escape road.
Third Safety Car period came on lap 22 when Liam Lawson stopped due to a problem with his fire extinguisher. The restart came on lap 25 and Piastri immediately struggled hard when he had a lock-up in turn 1 and Zhou almost passed. However, the PREMA driver stayed in front. Further back in the field there was also a contact between Ticktum and Boschung. The Carlin driver went off the track but was able to continue unharmed.
Final Safety Car phase came on the penultimate lap after an incident involving David Beckmann and Bent Viscaal in turn 1. The race ended behind the Safety Car, and Piastri took the checkered flag. His title rival Zhou was second. Ticktum, who changed to soft tires, finished third after fighting his way from the back.
The top 10 of the Formula 2 Feature Race at Monza:
| Pos. | Driver | Team | Gap |
| 1 | Oscar Piastri | PREMA Racing | 56:39.491 |
| 2 | Guanyu Zhou | UNI-Virtuosi | +1.043 |
| 3 | Dan Ticktum | Carlin | +1.818 |
| 4 | Theo Pourchaire | ART GP | +2.066 |
| 5 | Jehan Daruvala | Carlin | +2.445 |
| 6 | Robert Shwartzman | PREMA Racing | +2.728 |
| 7 | Richard Verschoor | MP Motorsport | +3.330 |
| 8 | Lirim Zendeli | MP Motorsport | +3.560 |
| 9 | Roy Nissany | DAMS | +3.964 |
| 10 | Marcus Armstrong | DAMS | +4.477 |
